Considering the alarming increase in the statistics of infidelity and divorce, this research was conducted with the aim of comparing the effectiveness of mindfulness-based cognitive therapy and acceptance and commitment therapy on depression and life expectancy of women affected by marital infidelity. This research was a semi-experimental with a pre-test-post-test design with a control group. The statistical population consisted of women affected by marital infidelity in Tabriz in 1401. 45 participants were selected by purposeful sampling method and placed in three groups (15/group). The experimental groups received the treatment specific to their group in 8 sessions. The measurement tools included Beck's depression and Schneider's life expectancy questionnaires. The data were analyzed by multivariate analysis of covariance and post-hoc Bonferroni test. The results showed that both treatments reduced depression and increased the life expectancy of women affected by marital infidelity in the post-test compared to the control group (P<0.001). Also, the effect of treatments on depression and life expectancy of women affected by marital infidelity in the post-test stage was not statistically different. The results proved that mindfulness-based cognitive therapy and acceptance and commitment therapy can reduce depression and increase the life expectancy of women affected by marital infidelity.