The present study was conducted with the aim of predicting aggressive behaviors in men with self-injury experience based on family affective climate and parental religiousness. The research method used was a descriptive correlational type and the statistical population of this research included all the men who had self-injury experience in West Azerbaijan province in 2023, from which 190 people were selected by Convenience Sampling and answered the Parental Religiousness questionnaire (1998), Family affective climate questionnaire (1964), and Buss Perry Aggression questionnaire (1992). The results showed parental religiousness predicts aggressive behaviors (R2=0.469, P>0/001) and mother’s religious leaning has a negative relation with aggressive behaviors (β=-0.528, P>0/001) and father’s religious leaning also has a negative relation with aggressive behaviors (β=-0.222, P>0/001). Family affective climate was also found to predict aggressive behaviors (except father-son relationship) (R2=0.196, P>0/001) and mother-son relationship had a negative relationship with aggressive behaviors (β=-0.421, P=0/001). In conclusion, this study sheds light on the significant relationship between family affective climate, parental religiousness, and aggressive behavior in men who engage in self-mutilation. These findings call for early intervention and therapeutic methods that address both religious experiences and families' emotional climate to prevent aggressive actions.