The present study aimed to investigate the effectiveness of narrative therapy on reproductive quality of life and infertility self-efficacy in couples experiencing infertility. This quasi-experimental study employed a pre-test, post-test, and follow-up design with a control group. The study population comprised all infertile individuals who visited infertility centers and clinics during the first half of 2025. From this population, 32 individuals were selected using a non-probability sampling method based on specific inclusion and exclusion criteria and were assigned to either the experimental or control groups. The experimental group received narrative therapy in eight 90-minute sessions following a standardized protocol, while the control group received no intervention. Measurement tools included the Reproductive Quality of Life Questionnaire (Boivin et al., 2011) and the Infertility Self-Efficacy Questionnaire (Cousineau et al., 2006). Data were analyzed using mixed-design analysis of variance (ANOVA) with repeated measures in SPSS version 26. The findings indicated that narrative therapy significantly improved reproductive quality of life and infertility self-efficacy in the experimental group at both post-test and follow-up stages compared to the control group. Therefore, narrative therapy appears to be an effective intervention for enhancing reproductive quality of life and infertility self-efficacy in couples facing infertility.